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More on Pet Meds. You must consult your doctor if you have any pre-existing medical conditions including liver or kidney disease, heart disease, congestive heart failure, diabetes or digestive problems. It is important that you inform your doctor if you are pregnant, planning to conceive or breastfeeding as Procardia XL may cause harm to unborn and new born babies.
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Information for Patients Nifedipine extended release tablets should be swallowed whole. Do not chew, divide, or crush tablets. Do not be concerned if you occasionally notice in your stool something that looks like a tablet. In nifedipine extended release tablets, the medication is contained within a nonabsorbable shell that has been specially designed to slowly release the drug for your body to absorb. When this process is completed, the empty tablet is eliminated from your body.
The relationship to nifedipine therapy is uncertain in most cases, but probable in some. These laboratory abnormalities have rarely been associated with clinical symptoms; however, cholestasis with or without jaundice has been reported. This was an isolated finding not associated with clinical symptoms and it rarely resulted in values which fell outside the normal range.
Rare instances of allergic hepatitis have been reported. In controlled studies, nifedipine extended release did not adversely affect serum uric acid, glucose, or cholesterol. Serum potassium was unchanged in patients receiving nifedipine extended release in the absence of concomitant diuretic therapy, and slightly decreased in patients receiving concomitant diuretics. Nifedipine, like other calcium channel blockers, decreases platelet aggregation in vitro.
Limited clinical studies have demonstrated a moderate but statistically significant decrease in platelet aggregation and an increase in bleeding time in some nifedipine patients.
This is thought to be a function of inhibition of calcium transport across the platelet membrane. No clinical significance for these findings has been demonstrated. Although nifedipine has been used safely in patients with renal dysfunction and has been reported to exert a beneficial effect, in certain cases, rare, reversible elevations in BUN and serum creatinine have been reported in patients with pre-existing chronic renal insufficiency.
The relationship to nifedipine therapy is uncertain in most cases but probable in some. Experience in over patients with nifedipine extended release capsules in a noncomparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension, or exacerbation of angina.
Long-acting Nitrates Nifedipine may be safely co-administered with nitrates, but there have been no controlled studies to evaluate the antianginal effectiveness of this combination.
Digitalis Administration of nifedipine with digoxin increased digoxin levels in nine of twelve normal volunteers. Another investigator found no increase in digoxin levels in thirteen patients with coronary artery disease.
In an uncontrolled study of over two hundred patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. Coumarin Anticoagulants There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered.
However, the relationship to nifedipine therapy is uncertain. Ranitidine produced smaller, non-significant increases.
The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised. Carcinogenesis, Mutagenesis, Impairment of Fertility Nifedipine was administered orally to rats for two years and was not shown to be carcinogenic. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 30 times the maximum recommended human dose.
There is a literature report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro. In vivo mutagenicity studies were negative. Pregnancy Pregnancy Category C Nifedipine has been shown to produce teratogenic findings in rats and rabbits, including digital anomalies similar to those reported for phenytoin.
Digital anomalies have been reported to occur with other members of the dihydropyridine class and are possibly a result of compromised uterine blood flow. There are no adequate and well-controlled studies in pregnant women. Nifedipine extended release tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Pediatric Use Safety and effectiveness in pediatric patients have not been established. All side effects reported during nifedipine extended release tablet therapy were tabulated independent of their causal relation to medication.
Drug interactions may change how your medications work or increase your risk for serious side effects. Hemodynamic studies in patients with generic ventricular price have generally price a procardia increase in generic index without major effects on ejection fraction, left ventricular end diastolic pressure LVEDPor volume LVEDV, procardia xl generic price. Do not suddenly stop taking this medication without consulting your doctor, procardia xl generic price. Procardia your doctor right procardia if any of these unlikely but serious side effects occur: Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Most price with high blood pressure do not feel generic. Patients recently withdrawn from beta blockers may develop a withdrawal syndrome with increased angina, probably related to increased sensitivity to catecholamines. Generic drugs can be more cost effective than purchasing the brand name. Make yourself an instant PS Card now. Lowering high blood pressure helps prevent strokes, heart attacksprocardia xl generic price, and kidney problems. Dosage is based on your medical condition and response to treatment. Never stop or change your medication dosage without consulting your doctor. These laboratory abnormalities have rarely been associated with clinical symptoms; however, cholestasis with or without jaundice has been reported.
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